Glycoprotein Biosynthesis in Small Intestinal Mucosa

Glycoprotein Biosynthesis in Small Intestinal Mucosa

An active multiglycosyltransferase system involved in the transfer of N-acetylgalactosamine, N-acetylglucosamine, and galactose to various glycoprotein acceptors was found in the rat small intestinal mucosa. The present studies are concerned with the subcellular localization of these glycosyltransferases. Satisfactory isolation of smooth and rough surfaced microsomes from the intestinal mucosa ...

Biosynthesis of lipoprotein by rat intestinal mucosa.

Lymph chylomicrons are at the lipid-rich end of the spectrum of the lipoproteins. The nature of their protein moiety and its biosynthesis have not yet been fully elucidated. Observations are reported on the incorporation of radioactive leucine into a “lowest density lipoprotein” by mucosal cells of the small intestine isolated from the rat during absorption of fat. The amino acid incorporation ...

Glycoprotein synthesis and secretion by cultured small intestinal mucosa in coeliac disease.

Glycoprotein biosynthesis by jejunal mucosa was examined during culture in vitro in 26 patients with coeliac disease and 19 controls. The incorporation rates of tritiated glucosamine into tissue and secreted glycoproteins were determined using established techniques. The total glucosamine incorporation in untreated coeliac patients was significantly greater than that of histologically normal mu...

Significance of a Flat Small-intestinal Mucosa.

Malignancy and the Small-intestinal Mucosa.

The observations presented here suggest that malignancy anywhere in the body may be accompanied by a secondary change in the small-intestinal mucosa, including the flattened appearance that is usually seen in idiopathic steatorrhoea. The reverse of this association, that idiopathic steatorrhoea may be complicated by a reticulosis, has been reported by Gough et al. (1962). They described four ca...